Abstract Puts forward the concept of competitive advantage of industrial technology, and discusses its "scale, quality and value" threedimensional model and measurement index system. Construction of industrial technology competitive advantage index, using entropy method to set weights; the index of competitive advantage of industrial technology was calculated by synthetic index method. The sample data of major countries in the world biomedical industry(China, the United States, Germany, and Japan) from 1996 to 2016 were used for empirical research. The results showed that the technical competitive advantage index and subindex of the Chinese biomedical industry were on the rise, with the scale index growing fast, the value index second, and the quality index ranking at the bottom. The United States, Japan and Germany have similar competitive advantage index and have strong competitive advantage. In terms of scale, the gap between China and other three countries is smaller, the value dimension is less, and the quality dimension is larger.