Abstract By quantitative analysis of the nationality distribution of the Nobel prize winner in science of 1901-2016 we can find the general situation of the world science and technology activity center shifting from Germany to the United States and the development trend of the current research of science and technology in the world: the countries in Europe is the focus of research of science and technology in the world and the United States is the world center for science and technology activity. But this position is not very stable. As all the countries pay attention to the research of science and technology the development of science and technology in the world toward multi polarization has emerged, which has important enlightenment value for our country's system reform and policy adjustment of science and technology.
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